Should I panic
- Code red - drop everything and investigate
- Purple striae + growth deceleration (Cushing’s calling)
- Toddler with acanthosis nigricans (syndromic acanthosis nigricans)
- Segmental hyperpigmentation + early puberty (McCune Albright)
- Lip bumps + thyroid disease + constipation (tumor alert)
- Orange alert - definitely worth a look
- Persistent hirsutism + irregular menses (PCOS)
- Yellow soles + fatigue + diffuse alopecia (hypothyroidism)
- Recurrent skin infections + polyuria (DM1)
- Green light - keep calm and carry on
- Isolated skin tags
- Mild acanthosis nigricans in typical teenage obesity care
Mecanismos
- Efeito direto da hormona na pele
- Efeito indireto por dano visceral ou tecidular
Achados Clínicos Importantes a procurar
- Hirsutism/hair changes
- Obesity patterns/fat distribution
- Rashes (acanthosis nigricans, striae, necrobiosis)
- Mucosal changes
- Other pigmentary changes
- Nail alterations
- Edema/skin texture changes
- Skeletal proportions/Growth patterns
Organização
- Pancreas
- Pituitary gland
- Adrenal gland → 2 ebriologically and fucntional different tissues
- Adrenal cortex
- Hyperandrogenism → hirsutism Addison Disease
- Adrenal medulla
- Cushing
- Sex hormones
- Hyperandrogenism
- Hypoandria
- Hyperestrogenism Síndrome Ovário Poliquistico
- Adipose tissue
- Multiple systems
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