Cardiovascular Disease

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Endocarditis skin clinical manifestations
  • Osler nodules
  • Janeway’s spots
  • Conjunctival and subungueal hemorrhages
  • Vasculitis induced purpura
 
Hypertrophic Osteoarthropathy | Pachydermoperiostosis
 
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Those with higher health consequences → more important
  • Arterial rupture during delivery in Ehlers-Danlos Type IV (defective type III collagen)
 
Keratodermas
  • Naxos Syndrome
    • Plakoglobin
    • Right side cardiomiopathy
    • Wooly hair
    • NEPPK (non-epidermolytic palmoplantar keratoderma)
  • Carvajal Syndrome
    • Desmoplakin
    • Left side cardiomyopathy
    • Wooly hair
    • NEPPK (non-epidermolytic palmoplantar keratoderma)
 
Pseudoxanthoma Elasticum
 
Differential Diagnosis of Angioid Streaks - “C-APPLE PITS”
  • Cowden
  • Acromegaly
  • Pseudoxanthoma elasticum
  • Paget hyperphosphatemia
  • Lead poisoning
  • Ehlers-Danlos
  • Pituitary adenoma
  • Increased ICP, ITP
  • Trauma, Thalassemia
  • Sickle cell anemia, hereditary spherocytosis